Advanced Photonic Structures for Biological and Chemical Detection (Integrated Analytical Systems)

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D G Peacock. Integrated Nanophotonic Devices. Zeev Zalevsky. Veikko Lindroos. Conductive Atomic Force Microscopy. Mario Lanza. Alastair Buckley. Printed Electronics. Zheng Cui. Optical Tweezers. Giovanni Volpe. Max Lu. Semiconductor Laser Engineering, Reliability and Diagnostics. Peter W. Nam-Trung Nguyen. Energy Storage. Robert Huggins.

Low Voltage Electron Microscopy. David C. Semiconductor Lasers. Alexei Baranov. Thin Film Shape Memory Alloys. Shuichi Miyazaki. Hydrodynamics of Gas-Liquid Reactors. Barry Azzopardi. Nonlinear Effects in Optical Fibers. Mario F. Scanning Probe Microscopy for Energy Research. Dawn A Bonnell. Transparent Oxide Electronics. Pedro Barquinha. Jaydeep Sarkar. Nano Optoelectronic Sensors and Devices.

Ning Xi. Heterogeneous Electrode Processes and Localized Corrosion. Yongjun Mike Tan. Isabella Nova. Carbon Nanotubes and Graphene for Photonic Applications. Shinji Yamashita. Compact Semiconductor Lasers. Richard De La Rue. Elsevier Science. Underneath the Bragg Peaks. Takeshi Egami. Acoustic Microscopy. Andrew Briggs. Materials Science of Thin Films. Milton Ohring. Thermal Analysis of Polymers. Joseph D.

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The high sensitivity of compact microphotonic devices can generate effective microfluidic sensors, with integration capabilities. By turning the technol. The authors overview some of the exciting developments so far. Multiple internal reflection poly dimethylsiloxane systems for optical sensing Lab Chip , 7 11 — DOI: Compact poly dimethylsiloxane -based PDMS multiple internal reflection systems which comprise self-alignment systems, lenses, microfluidic channels and mirrors have been developed for highly sensitive absorbance measurements.

With the proper definition of air mirrors at both sides of the sensing region, the optical path of the light from the LED has been meaningfully lengthened without a dramatic increase of the mean flow cell vol. By recursive positioning of such air mirrors, propagating multiple internal reflection PMIR systems have been designed, simulated and characterized.

The tailoring of the sensing region, following the optical path, results in a similar limit of detection nM for fluorescein dild. Finally, a ring configuration, labeled RMIR, has also been developed. With the addn. These results confirm the validity of the proposed systems for high sensitivity measurements. Arrays and cascades of fluorescent liquid-liquid waveguides: Broadband light sources for spectroscopy in microchannels Anal.

Micro-optics for microfluidic analytical applications

Mayers, Brian T. This paper describes the fabrication and operation of fluidic broadband light sources for use on-chip in integrated microanal. These light sources consist of liq. Simultaneous use of multiple fluorophores in a common soln. Two approaches circumvent this problem of energy transfer; both use spatial sepn. The 1st setup uses a cascade series of single-core, single-dye light sources of increasing absorption energy to generate a combined broadband output. The 2nd approach uses a parallel array of single-core, single-dye light sources.

The spectral content of the light output for both cascade and array light sources can be controlled through choice of flow rates and dyes. Output intensity from these light sources is comparable to std.

The paper also discusses the efficiency of energy transfer between parallel liq. We present an elec. The device can redirect light from an optical input channel into five output channels by exploiting total internal reflection TIR at a liq. The liq. EWOD actuators. The router is assembled from two chips fabricated by std. MEMS techniques. Through a combination of microfluidic with micro-optical components on chip, reliable light routing is achieved with switching times of [1.

The optofluidic approach enables addressing of multiple channels over a broad wavelength range. Such optical routing capabilities are important for lab-on-chip devices focusing on optical spectroscopy, optical detection, or even optical manipulation. When integrated with external light sources and a low-cost disposable photonic lab-on-a-chip, the router could thus lead to novel lab. The Beer-Lambert Law J.

  • Advanced Photonic Structures for Biological and Chemical Detection / Edition 1?
  • Juejun (JJ) Hu.

World , 15 4 64 DOI: Cell analysis using a multiple internal reflection photonic lab-on-a-chip Nat. Here we present a protocol for analyzing cell cultures using a photonic lab-on-a-chip PhLoC. By using a broadband light source and a spectrometer, the spectrum of a given cell culture with an arbitrary population is acquired.

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The PhLoC can work in three different regimes: light scattering using label-free cells , light scattering plus absorption using stained cells and, by subtraction of the two former regimes, absorption without the scattering band. The PhLoC, including microlenses, micromirrors and microfluidics, is simply fabricated in a single-mask process by soft lithog.

Because of its low cost it can easily be implemented for point-of-care applications. From raw substrates to final results, this protocol can be completed in 29 h. Enhancement of the response of poly dimethylsiloxane hollow prisms through air mirrors for absorbance-based sensing Talanta , 75 2 — DOI: Elsevier B. The hollow prisms are photonic lab-on-a-chip systems with a high degree of monolithic integration that consist of micro-optical prism and microlenses , microfluidics and structural elements self-alignment systems obtained in PDMS by soft lithog.

Due to the low refractive index contrast between the PDMS and the phosphate buffer that fills the hollow prism, the reflectivity at this interface is low, requiring long integration times. This severe limitation was tackled with the definition of an air mirror, which solves the low reflectivity problems: with the appropriate design, the working wavelength matches with the condition of total internal reflection TIR only at the air mirror and is reflected back to the hollow prism.

The use of air mirrors enhances the sensing properties of the hollow prisms due to several reasons: 1st, the integration time is strongly reduced, from 2. Although the integration time is reduced, the signal-to-noise ratio SNR is increased from 12 dB to As compared to the system without the air mirror, the sensitivity is increased by a factor between 1. Poly dimethylsiloxane hollow Abbe prism with microlenses for detection based on absorption and refractive index shift Lab Chip , 4 1 24 — 27 DOI: The authors report on an optical detection method that uses two phys. The device consists of a hollow prism and was fabricated by soft-lithog.

It exhibits a high degree of monolithic integration. To keep down the amt. Since all components are fabricated in the same material and in the same process, compatibility with other microfluidic devices or components can be achieved easily. The functional efficiency and the performance of the detector were tested by studying solns.

Optimization of poly dimethylsiloxane hollow prisms for optical sensing Lab Chip , 5 5 — DOI: A new generation of simple, robust and compact microfluidic systems with optical readout is presented. The devices consist of hollow prisms fabricated by soft-lithog. By modifying the vols. The limit of detection LOD for fluorescein and methyl orange dild. For the authors' studies the authors used concns. Finally, since the change in the fractions of the methyl orange as a function of the pH causes a variation of the total absorption of the soln. The detection principle is based on the formation of selective stable complexes between the heavy metal ion and the corresponding ligand.

This interaction modulates the ligand spectrum by giving rise to new absorbance bands or wavelength shifting of the existing ones. Acetonitrile solns. The optical behavior of all the tested systems followed the expected Beer-Lambert law. Thus, the best results were achieved with the one with the longest OPL, which showed a linear behavior in a concn.

Such a simple anal. Hybrid electronic tongue based on optical and electrochemical microsensors for quality control of wine Analyst , 7 — DOI: A multiparametric system able to classify red and white wines according to the grape varieties and for analyzing some specific parameters is presented. The system, known as hybrid electronic tongue, consists of an array of electrochem. The array of electrochem. The optofluidic system is entirely fabricated in polymer technol. The data obtained from these sensors has been treated with multivariate advanced tools; Principal Component Anal.

The results have demonstrated the utility of this system for distinguishing the samples according to the grape variety and year vintage and for quantifying several sample parameters of interest in wine quality control. A comparative study of different approaches for the selective immobilization of biomols. The motivation of this work is to set a robust and reliable protocol for the easy implementation of a biosensor device in a PDMS-based photonic lab-on-a-chip PhLoC.

A hollow prism configuration, previously reported for the colorimetric detection of analytes was chosen for this study. Here, the inner walls of the hollow prism were initially modified by direct adsorption of either polyethylene glycol PEG or polyvinyl alc. PVA linear polymers as well as by carrying out a light chem. All these processes introduced hydroxyl groups on the PDMS surface to a different extent. The hydroxyl groups were further silanized using a silane contg. The interaction between this group and a primary amine moiety enabled the selective covalent attachment of a biomol.

A thorough structural characterization of the resulting modified-PDMS substrates was carried out by contact angle measurements, X-ray photoelectron spectroscopic XPS anal. Using horseradish peroxidase as a model recognition element, different biosensor approaches based on each modification process were developed for the detection of hydrogen peroxide target analyte in a concn. The anal. However, important differences were obsd.

Advanced photonic structures for biological and chemical detection - CERN Document Server

Limit of detection. The statistical meaning of detection limit values in trace anal. Various methods of calcg. Dual photonic-electrochemical lab on a chip for online simultaneous absorbance and amperometric measurements Anal. A dual lab on a chip DLOC approach that enables simultaneous optical and electrochem. Both detection modes are integrated for the first time into a single detection vol.

The exptl. Besides, optical detection was evaluated by measuring the absorbance of ferricyanide solns. The results obtained therein coincide with those predicted by the Beer-Lambert law for a range of ferricyanide concns. LoD of 0. The DLOC was finally applied to the anal. Here, the consumption of the reagent of the reaction ferrocyanide was continuously monitored by amperometry whereas the product of the reaction ferricyanide was recorded by absorbance.

The DLOC presented good performance in terms of sensitivity and limit of detection, comparable to other fluidic systems found in the literature. Classification and characterization of different White grape juices by using a hybrid electronic tongue J. Food Chem. A multisensor system combined with multivariate anal. The proposed system, known as hybrid electronic tongue, consists of an array of electrochem. A total of 25 white grape juices representing the large variability of vines grown in the Northwest Iberian Peninsula were studied. The data obtained were treated with Principal Component Anal.

The first tool was used to train the system with the ref. The results show that the three ref. Besides, using the SIMCA, the system demonstrates high potential for classifying and discriminating grape varieties. Cell screening using disposable photonic lab on a chip systems Anal. A low-cost photonic lab on a chip with three different working regimes for cell screening is presented. Opposite to the std. An addnl. Biofunctionalized all-polymer photonic lab on a chip with integrated solid-state light emitter Light: Sci. After curing, the resulting xerogel solid structure retains the emitting properties of the fluorophore, which is evenly distributed in the xerogel matrix.

To re-direct the emitted light, the SSLE includes two sets of air mirrors that surround the xerogel. Its performance is assessed by measuring quinoline yellow, obtaining a limit of detection LOD of 0. A multiple path photonic lab on a chip for parallel protein concentration measurements Lab Chip , 15 4 — DOI: We propose a PDMS-based photonic system for the accurate measurement of protein concn.

As opposed to the state of the art approach, in the multiple path photonic lab on a chip MPHIL , analyte concn. Also, as opposed to the std. MPHIL has three main advantages: firstly the possibility of dynamically selecting the path length, always working in the absorbance vs. Secondly, a dramatic redn. Thirdly, since only one injection is required, the measurement time is minimized, reducing both contamination and signal drifts.

These characteristics are clearly advantageous when compared to com. Cells on chips Nature , — DOI: Microsystems create new opportunities for the spatial and temporal control of cell growth and stimuli by combining surfaces that mimic complex biochemistries and geometries of the extracellular matrix with microfluidic channels that regulate transport of fluids and sol. Further integration with bioanalytic microsystems results in multifunctional platforms for basic biol. Highly integrated microdevices show great promise for basic biomedical and pharmaceutical research, and robust and portable point-of-care devices could be used in clin.

Cell culture models in microfluidic systems Annu. Annual Reviews Inc. Microfluidic technol. In this review, we discuss the characterization of cell culture in microfluidic systems, describe important biochem. Finally, we consider the integration of anal. Microfabrication in biology and medicine Annu. Microfabrication uses integrated-circuit manufg. These objects can have miniature moving parts, stationary structures, or both. Microfabrication has been used for many applications in biol. These applications fall into four domains: tools for mol. Microfabricated device structures may provide significantly enhanced function with respect to a conventional device.

Sometimes microfabrication can enable devices with novel capabilities. These enhancing and enabling qualities are conferred when microfabrication is used appropriately to address the right types of problems. Herein, we describe microfabrication technol. We detail several classes of advantages conferred by microfabrication and how these advantages have been used to date.

Monolithically integrated biophotonic lab-on-a-chip for cell culture and simultaneous pH monitoring Lab Chip , 13 21 — DOI: A poly dimethylsiloxane biophotonic lab-on-a-chip bioPhLoC contg. The integrated optical elements made possible both absorption and dispersion measurements, which were comparable to those made in a com. These cells were efficiently trapped in the incubation chamber, where they proliferated with a classical spindle-shaped morphol.

During cell proliferation, pH changes in the culture medium due to cell metab. Development and integration of xerogel polymeric absorbance micro-filters into lab-on-chip systems Opt. Express , 20 21 — DOI: Optical Society of America. This work reports on the implementation of different absorption micro-filters based on a dye-doped hybrid org.

Microstructures contg. The filtering capacity as a function of dye concn. Zero passband transmittance values and relatively sharp stopband regions were achieved with all the filters, also showing rejection levels between -6 dB and dB. Click here to learn more. By continuing to use this site, you agree to our use of cookies.

We've also updated our Privacy Notice. Click here to see what's new. Grating couplers on planar waveguides can be used as integrated-optical sensors responding to 1 changes in the refractive index of a liquid sample covering the waveguide differential refractometer and 2 the adsorption and desorption, respectively, of molecules out of a gaseous or liquid sample on the waveguide gas or chemical sensor. A theory of the sensor sensitivities is developed; conditions for the waveguide parameters in order to obtain high sensitivities are derived.

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It is shown that effects 1 and 2 can be distinguished by measurements of the effective index changes of both the TE 0 and the TM 0 modes. In the analysis both nonporous and microporous waveguiding films are considered. Tiefenthaler and W. Lukosz Opt. Thomas M. Butler, Eishi Igata, Steve J. Sheard, and Neil Blackie Opt. Express 16 11 Kunz Appl. You do not have subscription access to this journal.